Enantioselective Total Synthesis of (+)-Psiguadial B.
نویسندگان
چکیده
The first enantioselective total synthesis of the cytotoxic natural product (+)-psiguadial B is reported. Key features of the synthesis include (1) the enantioselective preparation of a key cyclobutane intermediate by a tandem Wolff rearrangement/asymmetric ketene addition, (2) a directed C(sp(3))-H alkenylation reaction to strategically forge the C1-C2 bond, and (3) a ring-closing metathesis to build the bridging bicyclo[4.3.1]decane terpene framework.
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عنوان ژورنال:
- Journal of the American Chemical Society
دوره 138 31 شماره
صفحات -
تاریخ انتشار 2016